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學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過?(guo)基??(ji)因??(yin)編??(bian)輯?(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)??(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小?(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)?。??失??(shi)去??(qu)這??(zhe)個(gè)??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元?(yuan)件?(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激?(ji)酶?(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍?(yue)??，這??(zhe)就??(jiu)好?(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)?。更?(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活?(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白?(bai)?。這??(zhe)個(gè)??(ge)如?(ru)同?(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分?(fen)子??(zi)一?(yi)旦??(dan)缺??(que)失?(shi)??，就?(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)?(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的?(de)大??(da)規(guī)??(gui)模??(mo)爆?(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動(dòng)??(dong)駕??(jia)駛?(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失?(shi)靈??(ling)時(shí)??(shi)進(jìn)?(jin)行??(xing)加??(jia)速??(su)??，會(huì)?(hui)橫??(heng)沖?(chong)直??(zhi)撞?(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞?(huai)?。。