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原標(biāo)題：欧亚一卡二卡日本一卡二卡

學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)通??(tong)過?(guo)基??(ji)因??(yin)編?(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)?(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)?。??失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過?(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳?(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約?(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)?。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接?(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)?。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖?(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在?(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激?(ji)活?(huo)時?(shi)徹?(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆?(bao)發(fā)??(fa)??，如??(ru)同??(tong)自?(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直?(zhi)撞??(zhuang)造??(zao)成?(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)?。　　這??(zhe)個??(ge)比??(bi)喻??(yu)的??(de)背??(bei)后??(hou)是??(shi)雙??(shuang)重??(zhong)突??(tu)破??(po)：理??(li)論??(lun)上??(shang)首??(shou)次??(ci)證?(zheng)明??(ming)細(xì)??(xi)胞??(bao)周??(zhou)期??(qi)調(diào)??(tiao)控??(kong)蛋??(dan)白??(bai)能??(neng)指??(zhi)揮??(hui)非??(fei)分??(fen)裂??(lie)細(xì)??(xi)胞??(bao)的??(de)炎??(yan)癥??(zheng)反?(fan)應(yīng)??(ying)??，臨??(lin)床??(chuang)上?(shang)開??(kai)辟??(pi)了??(le)“一?(yi)藥??(yao)多??(duo)治??(zhi)”的??(de)可??(ke)能??(neng)性??(xing)??。??丁?(ding)勝?(sheng)表??(biao)示??(shi)??，這??(zhe)一??(yi)研??(yan)究?(jiu)不??(bu)僅??(jin)深??(shen)化??(hua)了??(le)人?(ren)們?(men)對??(dui)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)免??(mian)疫??(yi)調(diào)??(tiao)控??(kong)機(jī)??(ji)制??(zhi)的?(de)理??(li)解??(jie)??，也??(ye)為??(wei)未??(wei)來??(lai)開??(kai)發(fā)??(fa)神?(shen)經(jīng)??(jing)炎??(yan)癥??(zheng)相??(xiang)關(guān)??(guan)疾??(ji)病??(bing)的??(de)精??(jing)準(zhǔn)?(zhun)治??(zhi)療??(liao)策??(ce)略??(lve)提??(ti)供??(gong)了?(le)科??(ke)學(xué)?(xue)依??(yi)據(jù)??(ju)??。。