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學(xué)習(xí)快評(píng)丨qibao666888　　中??(zhong)新??(xin)網(wǎng)??(wang)北??(bei)京??(jing)3月??(yue)26日??(ri)電??(dian) 如??(ru)果??(guo)把??(ba)大??(da)腦??(nao)比??(bi)作??(zuo)處??(chu)于??(yu)精?(jing)密??(mi)運(yùn)??(yun)轉(zhuǎn)??(zhuan)中??(zhong)的??(de)自??(zi)動(dòng)??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)??，小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)就??(jiu)像??(xiang)是??(shi)車??(che)上??(shang)關(guān)??(guan)鍵??(jian)的??(de)“智??(zhi)能??(neng)車??(che)載??(zai)維??(wei)保??(bao)系??(xi)統(tǒng)??(tong)”??。??當(dāng)??(dang)其??(qi)中??(zhong)的??(de)核??(he)心??(xin)原??(yuan)件??(jian)——MEF2C基??(ji)因??(yin)出??(chu)現(xiàn)??(xian)故??(gu)障??(zhang)時(shí)?(shi)??，原??(yuan)本??(ben)的??(de)保??(bao)護(hù)??(hu)機(jī)??(ji)制??(zhi)就??(jiu)會(huì)??(hui)陷??(xian)入??(ru)混?(hun)亂??(luan)??，如??(ru)同??(tong)汽??(qi)車?(che)的??(de)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)失?(shi)靈??(ling)??，會(huì)??(hui)在??(zai)加?(jia)速??(su)時(shí)??(shi)失??(shi)控??(kong)、速??(su)度??(du)飆??(biao)升??(sheng)??。此??(ci)時(shí)??(shi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)切?(qie)換??(huan)到??(dao)“狂??(kuang)飆?(biao)”模??(mo)式?(shi)??，引?(yin)發(fā)??(fa)神??(shen)經(jīng)??(jing)炎??(yan)癥??(zheng)??，這??(zhe)便??(bian)是??(shi)自??(zi)閉??(bi)癥?(zheng)、阿??(e)爾??(er)茨??(ci)海??(hai)默??(mo)病??(bing)等??(deng)腦??(nao)疾??(ji)病??(bing)的??(de)重??(zhong)要??(yao)成??(cheng)因??(yin)???！　⊙??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過(guò)?(guo)基?(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)??(shi)驗(yàn)?(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源?(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除?(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個(gè)??(ge)“車?(che)速??(su)控?(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元?(yuan)件?(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷?(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過(guò)??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)?(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)?(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過(guò)??(guo)度??(du)活??(huo)躍?(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個(gè)??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹??(che)底?(di)釋??(shi)放??(fang)NF-κB信??(xin)號(hào)??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等?(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如?(ru)同??(tong)自??(zi)動(dòng)?(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會(huì)??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。。