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學(xué)習(xí)快評(píng)丨qibao666888　　中??(zhong)新??(xin)網(wǎng)??(wang)北??(bei)京??(jing)3月??(yue)26日??(ri)電??(dian) 如??(ru)果??(guo)把??(ba)大??(da)腦??(nao)比??(bi)作??(zuo)處??(chu)于??(yu)精??(jing)密??(mi)運(yùn)??(yun)轉(zhuǎn)??(zhuan)中??(zhong)的??(de)自??(zi)動(dòng)??(dong)駕?(jia)駛??(shi)汽?(qi)車(chē)??(che)??，小??(xiao)膠??(jiao)質(zhì)?(zhi)細(xì)??(xi)胞??(bao)就??(jiu)像??(xiang)是?(shi)車(chē)??(che)上??(shang)關(guān)??(guan)鍵??(jian)的??(de)“智??(zhi)能?(neng)車(chē)??(che)載??(zai)維?(wei)保??(bao)系??(xi)統(tǒng)??(tong)”??。??當(dāng)??(dang)其??(qi)中??(zhong)的??(de)核??(he)心??(xin)原??(yuan)件??(jian)——MEF2C基??(ji)因??(yin)出?(chu)現(xiàn)??(xian)故??(gu)障??(zhang)時(shí)??(shi)??，原??(yuan)本??(ben)的??(de)保??(bao)護(hù)??(hu)機(jī)??(ji)制秘(zhi)就?(jiu)會(huì)??(hui)陷??(xian)入??(ru)混??(hun)亂??(luan)??，如??(ru)同??(tong)汽??(qi)車(chē)??(che)的??(de)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)??，會(huì)?(hui)在??(zai)加??(jia)速??(su)時(shí)?(shi)失??(shi)控?(kong)、速?(su)度??(du)飆??(biao)升??(sheng)??。此??(ci)時(shí)??(shi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)切??(qie)換??(huan)到??(dao)“狂??(kuang)飆??(biao)”模??(mo)式??(shi)??，引??(yin)發(fā)??(fa)神??(shen)經(jīng)??(jing)炎?(yan)癥??(zheng)??，這??(zhe)便??(bian)是??(shi)自??(zi)閉??(bi)癥??(zheng)、阿??(e)爾??(er)茨??(ci)海??(hai)默??(mo)病??(bing)等??(deng)腦?(nao)疾??(ji)病??(bing)的??(de)重??(zhong)要??(yao)成??(cheng)因??(yin)???！　⊙??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過(guò)??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)?(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠?(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中?(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失?(shi)去?(qu)這??(zhe)個(gè)??(ge)“車(chē)??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入?(ru)混??(hun)亂?(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過(guò)??(guo)度??(du)反??(fan)應(yīng)?(ying)的??(de)p21蛋?(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被?(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過(guò)??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀?(hui)了??(le)RB蛋??(dan)白??(bai)??。這?(zhe)個(gè)??(ge)如??(ru)同??(tong)汽??(qi)車(chē)??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)?(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠?(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹?(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號(hào)??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)?(fa)TNF-α、IL-6等??(deng)炎?(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動(dòng)??(dong)駕??(jia)駛??(shi)汽??(qi)車(chē)??(che)在??(zai)速?(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會(huì)??(hui)橫?(heng)沖?(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破?(po)壞??(huai)??。。