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　　三九養(yǎng)生堂記者 鄧肯·蓋伊 報道

精彩|　　一??(yi)般??(ban)來??(lai)說??(shuo)??，母??(mu)系??(xi)家??(jia)族??(zu)史??(shi)(例??(li)如??(ru)姥??(lao)姥??(lao)、姨??(yi)媽?(ma))比??(bi)父??(fu)系??(xi)家??(jia)族??(zu)史??(shi)(比??(bi)如??(ru)奶??(nai)奶??(nai)、姑??(gu)媽?(ma))具??(ju)有??(you)更??(geng)高??(gao)的??(de)罹??(li)患??(huan)風??(feng)險??(xian)；一??(yi)級??(ji)親??(qin)屬??(shu)(例??(li)如??(ru)親??(qin)姐?(jie)妹??(mei)、母??(mu)親??(qin)、女??(nv)兒??(er))比??(bi)二??(er)級??(ji)親??(qin)屬??(shu)(例??(li)如??(ru)姥??(lao)姥??(lao)、姨?(yi)媽??(ma)、表??(biao)姐??(jie)妹??(mei))具??(ju)有??(you)更??(geng)高??(gao)罹??(li)患??(huan)風??(feng)險??(xian)??。??　　專??(zhuan)家??(jia)介??(jie)紹??(shao)?，直??(zhi)系??(xi)親??(qin)屬??(shu)中??(zhong)患??(huan)乳??(ru)腺??(xian)癌??(ai)的??(de)人??(ren)數(shù)??(shu)越??(yue)多??(duo)?，患??(huan)病??(bing)風??(feng)險??(xian)相??(xiang)應??(ying)越??(yue)大??(da)??。??如??(ru)有??(you)一?(yi)位??(wei)直??(zhi)系??(xi)親?(qin)屬??(shu)患??(huan)乳??(ru)腺??(xian)癌??(ai)?，則??(ze)患??(huan)病??(bing)的??(de)危??(wei)險??(xian)性??(xing)增??(zeng)加??(jia)1.5—3倍??(bei)；如??(ru)有??(you)兩??(liang)位??(wei)直??(zhi)系??(xi)親??(qin)屬??(shu)患??(huan)乳??(ru)腺??(xian)癌??(ai)?，則??(ze)患?(huan)病??(bing)率??(lv)將??(jiang)增??(zeng)加??(jia)7倍??(bei)；具??(ju)有??(you)遺??(yi)傳??(chuan)性??(xing)乳?(ru)癌?(ai)基??(ji)因??(yin)檢??(jian)測??(ce)為??(wei)BRCA1、BRCA2基??(ji)因??(yin)突??(tu)變??(bian)的??(de)患??(huan)者??(zhe)?，患??(huan)乳??(ru)腺??(xian)癌??(ai)、卵??(luan)巢??(chao)癌??(ai)和??(he)其??(qi)他??(ta)惡??(e)性??(xing)腫??(zhong)瘤?(liu)的??(de)風??(feng)險??(xian)增??(zeng)加??(jia)?，對??(dui)于??(yu)BRCA1突??(tu)變??(bian)攜??(xie)帶??(dai)者?(zhe)?，≤70歲??(sui)時??(shi)乳??(ru)腺??(xian)癌??(ai)累??(lei)積??(ji)風??(feng)險??(xian)為??(wei)55%—70%?，BRCA2突??(tu)變??(bian)攜??(xie)帶??(dai)者?(zhe)的??(de)相??(xiang)應??(ying)累??(lei)積??(ji)風?(feng)險??(xian)為??(wei)45%—70%；盡??(jin)管??(guan)上??(shang)述?(shu)數(shù)??(shu)據(jù)??(ju)表??(biao)明?(ming)有??(you)乳??(ru)腺??(xian)癌??(ai)家??(jia)族?(zu)史??(shi)的??(de)女??(nv)性??(xing)患??(huan)乳??(ru)腺??(xian)癌??(ai)概??(gai)率??(lv)成??(cheng)倍??(bei)增??(zeng)加??(jia)?，但?(dan)臨??(lin)床??(chuang)上??(shang)有??(you)乳??(ru)腺祝(xian)癌??(ai)家??(jia)族??(zu)史??(shi)的??(de)并??(bing)不?(bu)一??(yi)定?(ding)患??(huan)乳??(ru)腺??(xian)癌?(ai)??。據(jù)?(ju)相??(xiang)關??(guan)統(tǒng)??(tong)計??(ji)?，僅??(jin)15%—20%的??(de)乳?(ru)腺??(xian)癌??(ai)女??(nv)性??(xing)患??(huan)者??(zhe)有?(you)家??(jia)族??(zu)史??(shi)??。

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