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學(xué)習(xí)快評(píng)丨qibao666888　　北??(bei)京??(jing)時(shí)??(shi)間?(jian)3月??(yue)25日?(ri)??，清??(qing)華??(hua)大??(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁?(ding)勝??(sheng)教??(jiao)授??(shou)團(tuán)??(tuan)隊(duì)?(dui)在??(zai)國(guó)??(guo)際??(ji)頂??(ding)級(jí)??(ji)學(xué)??(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破??(po)性??(xing)研??(yan)究?(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小?(xiao)膠秘(jiao)質(zhì)??(zhi)細(xì)??(xi)胞?(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選?(xuan)出??(chu)能??(neng)精??(jing)準(zhǔn)??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系??(xi)統(tǒng)??(tong)的??(de)藥?(yao)物??(wu)小??(xiao)分?(fen)子??(zi)BMS265246??。??在??(zai)動(dòng)??(dong)物??(wu)實(shí)??(shi)驗(yàn)??(yan)中??(zhong)??，這??(zhe)種??(zhong)新??(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小?(xiao)鼠??(shu)的??(de)腦??(nao)部?(bu)炎?(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢??(hui)復(fù)?(fu)正??(zheng)常??(chang)??。這??(zhe)項(xiàng)??(xiang)發(fā)??(fa)現(xiàn)?(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細(xì)??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細(xì)??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄?(zhan)新?(xin)的??(de)實(shí)??(shi)例??(li)??，更祝(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路??(lu)徑??(jing)??。　　要??(yao)阻??(zu)止??(zhi)這??(zhe)場(chǎng)??(chang)細(xì)??(xi)胞??(bao)層??(ceng)面??(mian)的??(de)“暴??(bao)動(dòng)??(dong)”??，關(guān)??(guan)鍵??(jian)在??(zai)于?(yu)修??(xiu)復(fù)??(fu)失??(shi)靈?(ling)的??(de)“車??(che)速??(su)控??(kong)制??(zhi)”系??(xi)統(tǒng)??(tong)??。??研??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)構(gòu)??(gou)建?(jian)了??(le)獨(dú)??(du)特??(te)的??(de)藥??(yao)物??(wu)篩??(shai)選??(xuan)平??(ping)臺(tái)??(tai)??，用??(yong)熒??(ying)光??(guang)標(biāo)??(biao)記??(ji)細(xì)??(xi)胞?(bao)狀??(zhuang)態(tài)??(tai)并??(bing)結(jié)??(jie)合??(he)人??(ren)工?(gong)智??(zhi)能??(neng)分??(fen)析??(xi)??，對(duì)??(dui)2404種??(zhong)化??(hua)合??(he)物?(wu)進(jìn)??(jin)行??(xing)地??(di)毯??(tan)式??(shi)掃??(sao)描??(miao)??。經(jīng)??(jing)過(guò)??(guo)多??(duo)輪??(lun)篩??(shai)選??(xuan)??，一??(yi)個(gè)??(ge)代?(dai)號(hào)??(hao)為??(wei)BMS265246的??(de)小??(xiao)分??(fen)子?(zi)脫??(tuo)穎??(ying)而?(er)出??(chu)??。。