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學(xué)習(xí)快評丨qibao666888　　非??(fei)編??(bian)碼??(ma)RNA??，尤?(you)其??(qi)是??(shi)長??(chang)鏈??(lian)非??(fei)編??(bian)碼??(ma)RNA在?(zai)哺??(bu)乳??(ru)動??(dong)物??(wu)大??(da)腦??(nao)的??(de)發(fā)??(fa)育??(yu)、成??(cheng)熟?(shu)和??(he)疾??(ji)病??(bing)中??(zhong)發(fā)??(fa)揮??(hui)著??(zhe)重??(zhong)要?(yao)作??(zuo)用??(yong)??。??作??(zuo)為??(wei)此??(ci)次??(ci)的??(de)研??(yan)究??(jiu)亮??(liang)點??(dian)之??(zhi)一??(yi)??，團??(tuan)隊??(dui)首?(shou)次??(ci)整??(zheng)合??(he)了?(le)長??(chang)鏈??(lian)非??(fei)編??(bian)碼??(ma)RNA的??(de)空??(kong)間??(jian)表??(biao)達?(da)數(shù)?(shu)據(jù)??(ju)??，發(fā)??(fa)現(xiàn)??(xian)長??(chang)鏈??(lian)非?(fei)編??(bian)碼??(ma)RNA的??(de)表?(biao)達??(da)在??(zai)成??(cheng)年??(nian)小??(xiao)鼠??(shu)大??(da)腦?(nao)中?(zhong)具??(ju)有??(you)區(qū)?(qu)域??(yu)選??(xuan)擇??(ze)性??(xing)??，在??(zai)發(fā)??(fa)育??(yu)中??(zhong)的??(de)小??(xiao)鼠??(shu)大??(da)腦??(nao)內(nèi)??(nei)則??(ze)呈??(cheng)現(xiàn)??(xian)出??(chu)時?(shi)空??(kong)動??(dong)態(tài)??(tai)性??(xing)??，為?(wei)神??(shen)經(jīng)??(jing)功??(gong)能??(neng)與??(yu)非??(fei)編??(bian)碼??(ma)RNA相??(xiang)關(guān)?(guan)性??(xing)的??(de)研??(yan)究??(jiu)奠??(dian)定??(ding)了??(le)基??(ji)礎(chǔ)??(chu)??。(完??(wan))　　傳??(chuan)統(tǒng)??(tong)上??(shang)?，大??(da)腦?(nao)區(qū)??(qu)域?(yu)的??(de)邊??(bian)界??(jie)是??(shi)根??(gen)據(jù)?(ju)細(xì)??(xi)胞?(bao)結(jié)??(jie)構(gòu)??(gou)和??(he)功??(gong)能??(neng)定??(ding)義??(yi)的??(de)?，忽??(hu)略??(lve)了??(le)基??(ji)因??(yin)的??(de)轉(zhuǎn)??(zhuan)錄?(lu)特??(te)性??(xing)??。??利??(li)用??(yong)全??(quan)基??(ji)因??(yin)組??(zu)范??(fan)圍??(wei)的??(de)空??(kong)間??(jian)轉(zhuǎn)??(zhuan)錄??(lu)組??(zu)數(shù)??(shu)據(jù)??(ju)?，一??(yi)方??(fang)面??(mian)驗??(yan)證??(zheng)了??(le)基??(ji)于??(yu)轉(zhuǎn)??(zhuan)錄??(lu)組??(zu)特?(te)征??(zheng)劃??(hua)分??(fen)大??(da)腦?(nao)區(qū)??(qu)域??(yu)的??(de)可??(ke)行??(xing)性?(xing)?，另??(ling)一??(yi)方??(fang)面?(mian)通??(tong)過??(guo)空??(kong)間??(jian)聚??(ju)類??(lei)方??(fang)法?(fa)?，優(yōu)??(you)化??(hua)了??(le)鼠??(shu)腦??(nao)的??(de)腦??(nao)區(qū)??(qu)分??(fen)割??(ge)??。同??(tong)時?(shi)?，基??(ji)因??(yin)模??(mo)塊??(kuai)分??(fen)析??(xi)揭?(jie)示??(shi)了??(le)小??(xiao)鼠??(shu)大??(da)腦??(nao)不??(bu)同??(tong)區(qū)??(qu)域??(yu)的??(de)轉(zhuǎn)??(zhuan)錄??(lu)組??(zu)特??(te)征??(zheng)?，這??(zhe)為??(wei)理??(li)解??(jie)腦??(nao)區(qū)??(qu)特??(te)異??(yi)性??(xing)的??(de)分??(fen)子??(zi)機??(ji)制??(zhi)提??(ti)供??(gong)了??(le)重??(zhong)要??(yao)線??(xian)索??(suo)?，也??(ye)為??(wei)研??(yan)究??(jiu)其??(qi)他??(ta)物??(wu)種??(zhong)的??(de)大??(da)腦??(nao)分??(fen)區(qū)??(qu)提??(ti)供??(gong)了??(le)新??(xin)的??(de)方??(fang)法??(fa)論??(lun)支??(zhi)持??(chi)?，有??(you)望??(wang)推??(tui)動??(dong)對??(dui)大??(da)腦??(nao)復(fù)??(fu)雜??(za)結(jié)??(jie)構(gòu)??(gou)及??(ji)其??(qi)功??(gong)能??(neng)的??(de)深??(shen)入??(ru)理??(li)解??(jie)??。。