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學(xué)習(xí)快評(píng)丨qibao666888　　研??(yan)究?(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過(guò)??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)?(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基?(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個(gè)?(ge)“車??(che)速??(su)控??(kong)制??(zhi)系?(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的?(de)細(xì)?(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑祝(yi)制??(zhi)過(guò)??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳?(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過(guò)??(guo)度??(du)活??(huo)躍??(yue)直?(zhi)接??(jie)摧?(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這?(zhe)個(gè)??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安?(an)全?(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠?(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號(hào)??(hao)通?(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)?(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆?(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動(dòng)??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會(huì)??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　北??(bei)京??(jing)時(shí)??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華?(hua)大?(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁??(ding)勝??(sheng)教??(jiao)授??(shou)團(tuán)??(tuan)隊(duì)??(dui)在??(zai)國(guó)??(guo)際?(ji)頂??(ding)級(jí)??(ji)學(xué)??(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表?(biao)突??(tu)破??(po)性??(xing)研??(yan)究?(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關(guān)??(guan)鍵??(jian)開?(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多??(duo)種??(zhong)化?(hua)合??(he)物??(wu)中?(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準(zhǔn)??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系??(xi)統(tǒng)??(tong)的?(de)藥??(yao)物??(wu)小??(xiao)分??(fen)子?(zi)BMS265246??。??在??(zai)動(dòng)?(dong)物??(wu)實(shí)??(shi)驗(yàn)??(yan)中??(zhong)??，這??(zhe)種??(zhong)新?(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小??(xiao)鼠?(shu)的??(de)腦?(nao)部??(bu)炎?(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢??(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這??(zhe)項(xiàng)??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細(xì)??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細(xì)??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實(shí)??(shi)例??(li)??，更??(geng)為??(wei)治?(zhi)療?(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾?(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路?(lu)徑??(jing)??。。