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學(xué)習(xí)快評丨qibao666888　　北??(bei)京??(jing)時??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華??(hua)大??(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁??(ding)勝??(sheng)教??(jiao)授??(shou)團??(tuan)隊?(dui)在??(zai)國??(guo)際??(ji)頂??(ding)級??(ji)學(xué)??(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破??(po)性??(xing)研?(yan)究??(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中?(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精?(jing)準(zhǔn)??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系??(xi)統(tǒng)??(tong)的??(de)藥??(yao)物??(wu)小?(xiao)分??(fen)子??(zi)BMS265246??。??在??(zai)動??(dong)物??(wu)實??(shi)驗??(yan)中??(zhong)??，這?(zhe)種??(zhong)新?(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小??(xiao)鼠??(shu)的??(de)腦??(nao)部??(bu)炎??(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本?(ben)恢??(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這??(zhe)項??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實??(shi)例??(li)??，更??(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)提祝(ti)供??(gong)了??(le)全?(quan)新??(xin)路??(lu)徑??(jing)???！　≈??(zhong)新??(xin)網(wǎng)??(wang)北??(bei)京??(jing)3月??(yue)26日??(ri)電??(dian) 如??(ru)果??(guo)把??(ba)大??(da)腦??(nao)比?(bi)作??(zuo)處??(chu)于??(yu)精??(jing)密??(mi)運??(yun)轉(zhuǎn)??(zhuan)中??(zhong)的??(de)自??(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)??，小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)就?(jiu)像??(xiang)是??(shi)車??(che)上?(shang)關(guān)??(guan)鍵??(jian)的??(de)“智??(zhi)能??(neng)車??(che)載??(zai)維??(wei)保??(bao)系??(xi)統(tǒng)??(tong)”??。??當(dāng)??(dang)其??(qi)中??(zhong)的?(de)核??(he)心??(xin)原??(yuan)件??(jian)——MEF2C基??(ji)因??(yin)出??(chu)現(xiàn)??(xian)故??(gu)障??(zhang)時??(shi)??，原??(yuan)本??(ben)的??(de)保??(bao)護??(hu)機??(ji)制??(zhi)就??(jiu)會??(hui)陷??(xian)入??(ru)混?(hun)亂??(luan)??，如??(ru)同??(tong)汽??(qi)車??(che)的??(de)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)??，會??(hui)在??(zai)加??(jia)速?(su)時??(shi)失??(shi)控??(kong)、速??(su)度?(du)飆?(biao)升??(sheng)??。此??(ci)時??(shi)小??(xiao)膠??(jiao)質(zhì)?(zhi)細??(xi)胞??(bao)切??(qie)換??(huan)到??(dao)“狂??(kuang)飆?(biao)”模??(mo)式??(shi)??，引??(yin)發(fā)??(fa)神??(shen)經(jīng)??(jing)炎??(yan)癥??(zheng)??，這??(zhe)便??(bian)是??(shi)自??(zi)閉??(bi)癥??(zheng)、阿??(e)爾??(er)茨?(ci)海??(hai)默??(mo)病??(bing)等??(deng)腦??(nao)疾??(ji)病??(bing)的??(de)重??(zhong)要?(yao)成?(cheng)因??(yin)??。。